EndoAxis Formula 3 Restore for Detox Support contains focused nutrients to optimize phase 2 and phase 3 detox.
- Optimizes phase 2 and phase 3 detox pathways
- Improves biliary function
- Reduces oxidative stress while balancing hormones
Sex hormones are cholesterol-based signaling molecules (“steroid hormones”). This means that when they reach an expiration in circulation, our liver primarily (as well as fat tissue and colon) must transform those fat-based structures into a water-soluble intermediate through phase 1 detox (the CYP450 enzymes). Those intermediates then undergo phase 2 transformation through glucuronidation (UGT), Sulfation (SULT), Methylation (COMT), Acetylation (NAT) or direct glutathione reduction (GST). Once conjugated, these neutralized by-products can be easily bound to bile to excrete into urine or stool, a process called phase 3 detoxification.
Phase 2 detoxification of estrogen is dependent on several phase 2 enzymes, including methylation (COMT), Sulfation (SULT), glucuronidation (UGT) AND glutathione reduction. When we capture an imbalance or “backlog” of 2-OH estrogens, and witness lower production of 2-methoxy estrogens, OR when we see high levels of 16-OH estrogens, there may be concern for sluggish phase 2 and phase 3 de tox.
Whenever we address phase 1 or phase 2 detox, it is critical to also support phase 3, as the final elimination pathway of any hormone needs to be working optimally for all other upstream conjugation to occur in harmony with the body.
This evidence-based formulation targets phase 2 detox predominately through the use of folate-independent methylation pathways, sulfation, glutathione reduction and glucuronidation assistance.
Directions
Take 2 capsules 2 times a day with a meal or as directed by your healthcare practitioner.
Ingredients
Each serving of 2 capsules contains:
| Thiamin (as thiamin hydrochloride) |
12.5 mg |
| Riboflavin (as riboflavin 5-phosphate) |
12.5 mg |
| Niacin (as niacinamide) |
12.5 mg |
| Vitamin B6 (as pyridoxal-5-phosphate) |
10 mg |
| Folate (as calcium l-5-methyltetrahydrofolate) |
200 mcg |
| Vitamin B12 (as hydroxocobalamin) |
125 mcg |
| Magnesium (as 50% magnesium glycinate and 50% magnesium malate) |
26.3 mg |
| Molybdenum (as sodium molybdate) |
9.9 mcg |
| Trimethylglycine (as betaine anhydrous) |
250 mg |
| L-Methionine |
250 mg |
| Taurine |
200 mg |
| N-acetyl-L-cysteine |
100 mg |
| Broccoli (Brassica oleracea italica) (seed) powder extract (13% glucoraphanin) (TrueBroc®) |
25 mg |
| L-Serine |
25 mg |
Other Ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate, and silicon dioxide.
Made Without: Corn, soy, or wheat.
Warnings
Do not use if pregnant or nursing. Consult your physician before use if you have a medical condition, or taking any medication. Do not use product if the safety seal is broken or damaged. Keep out of reach of children.
EndoAxis formulated this product WITHOUT the use of methyl-B12. This was a decision made intentionally, as EndoAxis wants their products to be tolerated by all patients and intended for longer term use without concern. An additional methyl-B12 complex could be considered for short term or pulsed into the formulation as needed, but EndoAxis leaves that up to your professional discretion.
General Safety Information
- Always read the label. Use only as directed.
- Nutritional supplements may only be of assistance if the dietary intake is inadequate.
- Supplements should not be used to replace a healthy balanced diet and adequate physical exercise.
- Keep all medications and supplements out of reach of children.
- If symptoms persist see your healthcare professional.
