EndoAxis Formula 3.5 Restore for Detox Support contains focused nutrients to optimize phase 2 and phase 3 detox.
- Optimizes phase 1, 2 and 3 detox pathways
- Improves gastrointestinal health
- Reduces oxidative stress while balancing hormones
Sex hormones are cholesterol-based signaling molecules (“steroid hormones”). This means that when they reach an expiration in circulation, our liver primarily (as well as fat tissue and colon) must transform those fat-based structures into a water-soluble intermediate through phase 1 detox (the CYP450 enzymes). Those intermediates then undergo phase 2 transformation through glucuronidation (UGT), Sulfation (SULT), Methylation (COMT), Acetylation (NAT) or direct glutathione reduction (GST). Once conjugated, these neutralized by-products can be easily bound to bile to excrete into urine or stool, a process called phase 3 detoxification.
Phase 2 detoxification of estrogen is dependent on several phase 2 enzymes, including methylation (COMT), Sulfation (SULT), glucuronidation (UGT) AND glutathione reduction. When we capture an imbalance or “backlog” of 2-OH estrogens, and witness lower production of 2-methoxy estrogens, OR when we see high levels of 16-OH estrogens, there may be concern for sluggish phase 2 and phase 3 de tox.
Whenever we address phase 1 or phase 2 detox, it is critical to also support phase 3, as the final elimination pathway of any hormone needs to be working optimally for all other upstream conjugation to occur in harmony with the body.
These evidence-based formulation targets phase 1 and 2 detox pathways, coupled with potent phase 3 support to ensure transformation and conjugation of our sex hormones occurs in an appropriate and healthy manner.
Directions
Take 2 capsules 2 times a day with a meal or as directed by your healthcare practitioner.
Ingredients
Each serving of 2 capsules contains:
| Thiamin (as thiamin hydrochloride) |
15 mg |
| Riboflavin (as 50% riboflavin and 50% riboflavin 5-phosphate) |
15 mg |
| Niacin (as niacinamide) |
50 mg |
| Vitamin B6 (as pyridoxal-5-phosphate) |
7.5 mg |
| Folate (as calcium l-5-methyltetrahydrofolate) |
200 mcg |
| Vitamin B12 (as hydroxocobalamin) |
125 mcg |
| Calcium (as calcium d-glucarate) |
32.5 mg |
| Magnesium (as 50% magnesium glycinate and 50% magnesium malate) |
13.1 mg |
| Molybdenum (as sodium molybdate) |
14.9 mcg |
| Calcium D-Glucarate (Tetrahydrate Form) |
250 mg |
| Trimethylglycine (as betaine anhydrous) |
250 mg |
| Taurine |
150 mg |
| N-acetyl-L-cysteine |
100 mg |
| L-Methionine |
75 mg |
| BioResponse DIM® Proprietary Complex (Starch, diindolylmethane, Vitamin E [as tocophersolan], phosphatidyl choline, silica) |
50 mg |
| Broccoli (Brassica oleracea italica) (seed) powder extract (13% glucoraphanin) (TrueBroc®) |
25 mg |
| L-Serine |
15 mg |
Other Ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate, and silicon dioxide.
Made Without: Corn, soy, or wheat.
Warnings
Do not use if pregnant or nursing. Consult your physician before use if you have a medical condition, or taking any medication. Do not use product if the safety seal is broken or damaged. Keep out of reach of children.
General Safety Information
- Always read the label. Use only as directed.
- Nutritional supplements may only be of assistance if the dietary intake is inadequate.
- Supplements should not be used to replace a healthy balanced diet and adequate physical exercise.
- Keep all medications and supplements out of reach of children.
- If symptoms persist see your healthcare professional.
