Xylocaine 2% Jelly are indicated as a surface anaesthetic and lubricant for:
•The male and female urethra during cystoscopy, catheterisation, exploration by sound and other endourethral procedures.
•Nasal and pharyngeal cavities in endoscopic procedures such as gastroscopy and bronchoscopy.
•During proctoscopy and rectoscopy.
•To relieve pain after circumcision in children.
Xylocaine 2% Jelly provides prompt and profound anaesthesia of mucous membranes and lubrication which reduces friction. Its water-miscible base, characterised by high viscosity and low surface tension, brings the anaesthetic into intimate and prolonged contact with the tissue, giving effective anaesthesia of long duration (approx. 20-30 min). Anaesthesia usually occurs rapidly (within 5 min, depending upon the area of application).
Lignocaine like other local anaesthetics, causes a reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the nerve membrane. Local anaesthetics of the amide type are thought to act within the sodium channels of the nerve membrane.
Local anaesthetic drugs may also have similar effects on excitable membranes in the brain and myocardium. If excessive amounts of drug reach the systemic circulation rapidly, symptoms and signs of toxicity will appear, emanating from the central nervous and cardiovascular systems