Practitioner Range

Metagenics

Metagenics CholCare
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  • Metagenics CholCare

Practitioner Range

Metagenics

Metagenics CholCare
Free Gift

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  • Description
  • Reviews
  • Practitioner Range

Clinically Trialled Combination to Help Healthy People Maintain Normal Levels of Cholesterol and Triglycerides.

In healthy people, ingredients in CholCare have been shown to or may:

  • Help maintain healthy total cholesterol levels.
  • Improve LDL:HDL ratio by 26% in four weeks.1
  • Clinically trialled, once daily dose.
Clinical Benefits
  • The combination of 270 mg of citrus bioflavonoids (PMF-source?) and 18 mg of tocotrienols (TocoSource?), has been shown to impact total cholesterol by an average of 25% over 4 weeks and 27% over 12 weeks1: Three studies including a double blind, randomised clinical trial plus two open-label trials demonstrated significant reductions in total cholesterol, triglycerides and LDL:HDL ratio (Figure One).1
Figure One: Citrus Bioflavonoids and Tocotrienol Combination Impact Cholesterol in a Clinical Trial with 120 subjects.

Figure One: Citrus Bioflavonoids and Tocotrienol Combination Impact Cholesterol in a Clinical Trial with 120 subjects.

  • Key mechanisms include HMG-CoA reductase inhibition, reduction of apolipoprotein-B100 secretion and modulation of hepatic LDL receptors.2,3 Specifically, the polymethoxyflavones tangeretin and nobiletin, suppress the hepatic secretion of ApoB and increase LDL receptor synthesis.4,2 PMF-source? is an exclusive extract of citrus bioflavonoids containing at least 11.5 mg of tangeretin and 10 mg nobiletin per dose.
Figure Two: Ingredients in CholCare act upon multiple points within the Mevalonate Pathway.

Figure One: Citrus Bioflavonoids and Tocotrienol Combination Impact Cholesterol in a Clinical Trial with 120 subjects.

  • TocoSource? tocotrienols inhibit the production of HMGCoA reductase but support endogenous CoQ10 production via induction of the enzyme geranylgeranyl pyrophosphate (GGPP)2. In vitro research shows an 80% inhibition of HMG-CoA reductase by decreasing transcription efficiency and enhancing degradation, unlike most HMG-CoA reductase inhibitors which block the mevalonate pathway by up to 99%.5
Directions

Adults: Take 1 capsule at night.

Ingredients

Each capsule contains:

 

Citrus bioflavonoids extract (PMF-source?)

270 mg

Tocotrienols complex - palm* (TocoSource?)

18 mg

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