Duromine 30mg 30 Tablets (NZ PRESCRIPTION ONLY)
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Style number: 203548
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DUROMINE 30 mg capsules
Grey and reddish brown hard gelatin capsules with the caption DUROMINE 30 printed in white in the axial direction on each capsule half. Each capsule contains phentermine ion-exchange resin complex that releases phentermine 30 mg.
Phentermine is a sympathomimetic amine chemically related to amphetamine with significant anorectic activity in animal models. Its appetite suppressant effect is generally considered to be exerted through the hypothalamus but it is not certain that this is the only effect related to weight loss. Phentermine has major effects on the dopaminergic and noradrenergic nervous systems. In addition to effects upon appetite suppression in the CNS, phentermine may also have peripheral effects related to lipid metabolism. The cardiovascular effects include a pressor response and an increase in heart rate and force of contraction.
Phentermine (phenyl tertiary butylamine) ion-exchange resin complex is quite stable, highly insoluble and without pharmacological effect until it reacts with cations (hydrogen, potassium, sodium, etc) present in the gastrointestinal fluids. Phentermine is then released from the resin complex at a rate dependent on the total concentrations of these cations. Since this concentration is fairly constant throughout the entire gastrointestinal tract, continuous and controlled ionic release occurs over a 10 to 14 hour period. Absorption of phentermine is almost complete. The rate of absorption from the resin complex is significantly slower than that from the hydrochloride salt, resulting in a lower and later peak blood level. Phentermine is readily absorbed from the gastrointestinal tract and approximately 70 to 80% of an oral dose is excreted unchanged in the urine. The remainder is metabolised by the liver. The half-life of phentermine is about 25 hours. In one study in volunteers acidification of the urine reduced the half life to 7 to 8 hours.