Buccastem 3mg 10 Tabs -call 3734485 to order-

Can only be sold for treatment of nausea associated with migraine

Classification
Pharmacist Only Medicine

Dosage
Adults and children aged 12 years and over: One or two Buccastem 3mg Tablets twice a day.
Children under 12 years: Not recommended.
Elderly patients: There is no evidence that dosage need be modified for the elderly.

Ingredients
Each buccal tablet contains 3.0 mg prochlorperazine maleate BP.

Purpose/Usage
Buccastem 3mg is contraindicated in patients with impaired liver function, existing blood dyscrasias, epilepsy, Parkinsons Disease, prostatic hypertrophy, narrow angle glaucoma and known hypersensitivity to the active ingredient.

Precautions
Hypotension, usually postural, may occur, particularly in elderly or volume depleted patients. Tardive dyskinesia may occur occasionally, although this is normally associated with higher doses than are recommended for Buccastem 3mg. Nausea and vomiting as a sign of organic disease may be masked by the anti-emetic action of Buccastem 3mg.

There is inadequate evidence of the safety in human pregnancy, although prochlorperazine has been used for many years without apparent ill-effect. However, Buccastem should be avoided unless absolutely necessary during the first trimester of pregnancy. Since data from animal studies show that prochlorperazine may be found in breast milk, Buccastem 3mg should not be used during lactation.

The signs and symptoms will be predominantly extrapyramidal and may be accompanied either by restlessness and agitation or central nervous depression. Hypotension may also occur. Treatment is essentially symptomatic and supportive. There is no specific antidote. Gastric lavage is helpful, particularly when carried out within 6 hours of ingestion. Do not induce vomiting. Particular attention must be directed to maintaining a clear airway since this may be threatened by extrapyramidal muscle dystonias. Severe dystonic reactions usually respond to procyclidine (5-10 mg) or orphenadrine (20-40 mg) given i.m. or i.v. If convulsions occur they should be treated using i.v. diazepam. If hypotension is present, strict attention to ventilation and posturing of the patient will often secure the desired effect, but failing this, consideration should be given to volume expansion by i.v. fluids. If this is insufficient, positive inotropic agents such as dopamine may be tried, but peripheral vasoconstrictor agents are not generally recommended. Adrenaline should NOT be used.